Xintela publishes results from stem cell study

Xintela has previously reported positive preclinical results in a horse study where a joint cartilage injury was treated with horse stem cells (adult mesenchymal from adipose tissue) selected with Xintela's marker technology. The study showed that the stem cells were both safe and they protected cartilage and bone from degradation following cartilage injury. In the newly published article, stem cells, prepared in the same way as those used in the horse study, have been characterized in various cell studies for their biological function. The results show that the selected stem cells have a better ability to develop into cartilage cells and to bind to a cartilage injury than non-selected heterogeneous stem cells. The studies were partly performed in collaboration with a research group in Germany.

"The results show that Xintela's method for producing therapeutic stem cells has several biological advantages, which can be of great importance in the development of an effective stem cell therapy, including cartilage regeneration. The publication also describes how Xintela's selection method leads to homogeneous and consistent stem cell preparations, which has huge regulatory advantages in the development of a stem cell product", says Xintela's CEO Evy Lundgren-Åkerlund.

The publication:
Integrin a10b1-selected Equine MSCs have Improved Chondrogenic Differentiation, Immunomodulatory and Cartilage Adhesion Capacity. Uvebrant, K., Reimer Rasmusson, L., Talts, JF., Alberton, P., Aszodi, A., Lundgren-Akerlund, E. (2019) Ann Stem Cell Res, 1(1): 001-009.

To read the publication, visit: https://www.somatopublications.com/integrin-%CE%B110%CE%B21-selected-equine-mscs-have-improved-chondrogenic-differentiation-immunomodulatory-and-cartilage-adhesion-capacity.pdf 

Xintela AB (publ)
Evy Lundgren-Åkerlund, CEO
Tel: 070-329 18 71
Email: [email protected] 
Medicon Village
223 81 Lund
www.xintela.se 

The following documents can be retrieved from beQuoted
Xintela Pressrelease 2019-02-15.pdf

About Xintela
Xintela develops medical products within regenerative medicine and oncology based on its proprietary marker technology, XINMARK®. Xintela uses the technology to isolate and quality assure stem cells for the treatment of the joint disease osteoarthritis. Studies on horses have shown that the stem cells are safe and that they have a therapeutic effect on the articular cartilage and the underlying bone after an injury. Xintela has recently established its own GMP-facility to produce stem cells for clinical studies. In the oncology program, XINMARK® is used for the development of an antibody-based treatment (Antibody Drug Conjugate, ADC) against specific tumors with first focus on the aggressive brain tumor glioblastoma. Positive preclinical results from cell studies and animal model have shown that the ADC treatment has a targeting and killing effect on specific tumor cells supporting further development of the company's oncology business. Xintela is listed on Nasdaq First North Stockholm since 22 March 2016. Xintela's Certified Adviser at Nasdaq First North is Erik Penser Bank AB, +46 8-463 80 00.

If you want to open the text in your webbrowser click here
______________________________________________________
This information was sent by beQuoted
If you want more information, please go to www.beQuoted.com
To change your subscription, please inform [email protected]

beQuoted Press är en service till Dig som är intresserad av finansiell information. Med beQuoted Press underlättas företagens finansiella kommunikation till Dig och till nyhetsbyråer, aktieägare, placeringsrådgivare och andra intressenter på aktiemarknaden.

Vi hoppas att Du uppskattar denna service.